Some medications may not be administered with enteral formulas because they form precipitates that may clog the feeding tube and reduce drug absorption.
To avoid compromising nutritional status, minimize the amount of time that feeding is interrupted by using once or twice daily dosage regimens.
Beckwith, M. C., Feddema, S. S., Barton, R. G., & Graves, C. (2004). A Guide to Drug Therapy in Patients with Enteral Feeding Tubes: Dosage Form Selection and Administration Methods. Hospital Pharmacy, 39(3), 225–237. https://doi.org/10.1177/001857870403900308